Pathogenetic Grounds of Principles of Depotentiation of Lethal Effects Y. pestis toxins
https://doi.org/10.21055/0370-1069-2012-1(111)-92-93
Abstract
Lethal combination of lypoplyssacharide and mouse Y. pestis toxin is decreased by the use of effective preparation - Cytoflavinum, the antihypoxant of substrate and regulatory activity. The positive resolving impact to the lethal activity of toxins of plague microbe provides also Emoxipinum, the synthetic preparation, the effect of which is enhanced by the use of Contrykal, Klexan, hemodez.
About the Authors
G. A. Afanas'eva
Saratov State Medical University
Russian Federation
Russian Federation
N. P. Chesnokova
Saratov State Medical University
Russian Federation
Russian Federation
References
1. Afanas’eva G.A., Chesnokova N.P. [Molecular-cellular mechanism of disturbances of the blood rheological properties under influence of “mouse” toxin Y. pestis]. Saratov. Nauchno-Meditsin. Zh. 2007; 4:43–8.
2. Afanas’eva G.A., Chesnokova N.P. [ Significance of activation of lipid peroxidation in the development of cytopathogenic effects of fraction FII (“mouse” toxin)]. Vestn. Saratovs. Gosudars. Agrarn. Univer. N.I.Vavilova. 2008; 2:18–9
3. Afanas’eva G.A., Chesnokova N.P., Budnik I.A. [On the pathogenetic significance of activation of lipid peroxidation in the mechanisms of distur- bance of blood rheological properties in bacterial endotoxicosis]. Izvest. Vysh. Ucheb. Zaved. Povolz. Reg. Meditsin. Nauki. 2008; 1:3–8.
4. Bizenkova M.N., Chesnokova N.P., Romantsov M.G. [Metabolic ef- fects of Cytoflavinum in experimental acute hypoxic hypoxia]. Uspekhi Sovr. Estestv. 2007; 9:45–8. 5. Okovityi S.V. [Clinical pharmacology of anti-oxidants]. FARMindeks- Praktic. 2003; 5:85–111.
5. Baker E.E., Sommer H., Foster L.E. et.al. Studies on Immunization against Plague. I. The Isolation and Characterization of the soluble Antigen of Pasturella pestis. J. Immunol. 1952; 68:131-45.
6. Westphal O., Luderitz O., Bister F. Uber die extraction von bacterien mit phenol. Z. Naturfirsch. Teil. 1952; 7:533-69.
Review
For citations:
Afanas'eva G.A., Chesnokova N.P. Pathogenetic Grounds of Principles of Depotentiation of Lethal Effects Y. pestis toxins. Problems of Particularly Dangerous Infections. 2012;(1(111)):92-93. (In Russ.) https://doi.org/10.21055/0370-1069-2012-1(111)-92-93
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