Distribution of Tryptophan-Dependent Yersinia pestis Variants in the Altai Mountain Natural Plague Focus
https://doi.org/10.21055/0370-1069-2012-3-20-25
Abstract
Carried out is the analysis of spatial location of tryptophan-dependent variants of plague microbe in the territory of Altai mountain plague natural focus. 1166
Y. pestis strains isolated in 1990–2010, were studied as regards nutrient requirements. 140 of them (12 %) were determined as tryptophan-dependent. The highest occurence of such strains was registered in Ulandryk focal region (21.6 % in average). Among strains isolated in Tarkhatin focal region only 2.3 % were tryptophan-dependent, and in Kuray region they were absent. Thus, the data obtained suggest that spatial heterogeneity of
Y. pestis
subsp.
altaica in the focus takes place.
Y. pestis strains isolated in 1990–2010, were studied as regards nutrient requirements. 140 of them (12 %) were determined as tryptophan-dependent. The highest occurence of such strains was registered in Ulandryk focal region (21.6 % in average). Among strains isolated in Tarkhatin focal region only 2.3 % were tryptophan-dependent, and in Kuray region they were absent. Thus, the data obtained suggest that spatial heterogeneity of
Y. pestis
subsp.
altaica in the focus takes place.
About the Authors
A. I. Logachev
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
V. M. Korzun
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
E. P. Mikhailov
Altai Plague Control Station
Russian Federation
Russian Federation
E. N. Rozhdestvensky
Altai Plague Control Station
Russian Federation
Russian Federation
S. V. Balakhonov
Irkutsk Research Anti-Plague Institute of Siberia and Far East
Russian Federation
Russian Federation
References
1. Balakhonov S.V., Shestopalov M.Yu., Romanova I.F. [Results of the VNTR-analysis in a locus (5’-NAAA-3’)n of strains Yersinia pestis from the active natural foci of plague of Siberia]. Mol. Genet. Mikrobiol. Virusol. 2009; 3:14–7.
2. Balakhonov S.V., Verzhutsky D.B., Korzun V.M., Vershinin E.A., Nemchenko L.S., Chipanin E.V. et al.[Current state of natural plague foci in Siberia]. Zh. Inf. Patol. 2009; 16(3):16–20.
3. Korzun V.M., Grechany G.V. [Selective genetic control over animals abundance dynamics]. Baikal’sky Zool. Zh. 2009; 3:110–26.
4. Korzun V.M., Chipanin E.V., Innokent’eva T.I., Mikhailov E.P., Denisov A.V. [Dynamics of epizootic activity and abundance of Mongolian pika in the Altai mountain natural plague focus]. Probl. Osobo Opasn. Infek. 2010; (106):13–8.
5. Korzun V.M., Chipanin E.V., Innokent’eva T.I., Mikhailov E.P., Fomina L.A., Sotnikova T.V. et al. [Dispersal of the flea Ctenophyllus hirticrus and spreading of plague epizooties in Gorny Altai]. Med. Parazitol. Parazitarn. Bol. 2007; 41(3):206–17.
6. Logachev A.I., Balakhonov S.V., Bel’kova S.A., Shestopalov M.Yu., Mikhailov E.P., Astashin Yu.M. [Biological properties of tryptophan-depend- ed strains of plague microbe isolated in Gorny Altai]. Byul. RAMN 2004; 2(1):107–11.
7. Logachev A.I., Balakhonov S.V., Ivzhenko N.I., Astashin Yu.M., Vershinina T.I., Khabarov A.V. et al. [Properties of plague microbe strains iso- lated in Gorny Altai in 1990–1992, in acute epizootic process]. In: [Problems of Natural Focal and Zoonotic Infections in Siberia and Far East]. Chita; 1993. P. 97–9.
8. Martinevsky I.L., Stepanov V.M. [About tryptophan-depended plague microbe strains, and their reverse mutants]. Probl. Osobo Opasn. Infek. 1972; (25):104–8.
9. Onishchenko G.G., Kutyrev V.V., editors. [Natural Plague Foci in the Caucasus, Caspian Sea Region, Middle Asia and Siberia]. M.; 2004. 192 p.
10. Rokitsky P.F. [Biological Statistics]. Minsk; 1973. 320 p.
11. Chumakova I.V., Kozlov M.P. [Plague Agent as an Element of Epizootic Process System]. Stavropol; 2008. 248 p.
12. Burrows T.G., Bacon G. The effects of lose of different virulence determinants on the virulence and immunogenicity of strains of Pasteurella pestis. Brit. J. Exp. Patol. 1960; 41:38–44.
Review
For citations:
Logachev A.I., Korzun V.M., Mikhailov E.P., Rozhdestvensky E.N., Balakhonov S.V. Distribution of Tryptophan-Dependent Yersinia pestis Variants in the Altai Mountain Natural Plague Focus. Problems of Particularly Dangerous Infections. 2012;(3(113)):20-25. (In Russ.) https://doi.org/10.21055/0370-1069-2012-3-20-25
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