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Immunobiological Characteristics of Cholera Toxin B-Subunit

https://doi.org/10.21055/0370-1069-2012-3-67-70

Abstract

Carried out was immunobiological evaluation of cholera toxin B subunit preparations obtained using different experimental and production methods. It was demonstrated that B subunit preparations were non-toxic for biomodels and did not cause significant pathological alterations in their organs and tissues. They also did not alter the condition of immunocompetent cells at different stages of their cycle, and promote anti-toxic antibodies production. Thus, B subunit preparations under study can be considered as promising components of cholera vaccine.

About the Authors

S. N. Klyueva
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


T. N. Shchukovskaya
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


T. P. Shmel’Kova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


A. L. Kravtsov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


S. A. Bugorkova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


N. I. Smirnova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


O. A. Volokh
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


T. L. Zakharova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


N. I. Belyakova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


S. A. Eremin
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


A. K. Nikiforov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation


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Review

For citations:


Klyueva S.N., Shchukovskaya T.N., Shmel’Kova T.P., Kravtsov A.L., Bugorkova S.A., Smirnova N.I., Volokh O.A., Zakharova T.L., Belyakova N.I., Eremin S.A., Nikiforov A.K. Immunobiological Characteristics of Cholera Toxin B-Subunit. Problems of Particularly Dangerous Infections. 2012;(3(113)):67-70. (In Russ.) https://doi.org/10.21055/0370-1069-2012-3-67-70

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ISSN 0370-1069 (Print)
ISSN 2658-719X (Online)