Immunobiological Characteristics of Cholera Toxin B-Subunit
https://doi.org/10.21055/0370-1069-2012-3-67-70
Abstract
Carried out was immunobiological evaluation of cholera toxin B subunit preparations obtained using different experimental and production methods. It was demonstrated that B subunit preparations were non-toxic for biomodels and did not cause significant pathological alterations in their organs and tissues. They also did not alter the condition of immunocompetent cells at different stages of their cycle, and promote anti-toxic antibodies production. Thus, B subunit preparations under study can be considered as promising components of cholera vaccine.
About the Authors
S. N. Klyueva
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
T. N. Shchukovskaya
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
T. P. Shmel’Kova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. L. Kravtsov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
S. A. Bugorkova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
N. I. Smirnova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
O. A. Volokh
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
T. L. Zakharova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
N. I. Belyakova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
S. A. Eremin
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. K. Nikiforov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
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Review
For citations:
Klyueva S.N., Shchukovskaya T.N., Shmel’Kova T.P., Kravtsov A.L., Bugorkova S.A., Smirnova N.I., Volokh O.A., Zakharova T.L., Belyakova N.I., Eremin S.A., Nikiforov A.K. Immunobiological Characteristics of Cholera Toxin B-Subunit. Problems of Particularly Dangerous Infections. 2012;(3(113)):67-70. (In Russ.) https://doi.org/10.21055/0370-1069-2012-3-67-70
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