Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation
https://doi.org/10.21055/0370-1069-2012-4-33-35
Abstract
The preference of the (21±1) °C temperature for cultivation of the vaccine strain Yersinia pestis EV in the live plague vaccine biomass production to (27±1) °C is experimentally confirmed. An original interpretation of the mechanism of small cells stability that are formed at (21±1) °C has been proposed. This interpretation stipulates a smaller damaging effect of steam molecules during sublimation in the process of lyophilization.
About the Authors
D. A. Budyka
Stavropol Research Anti-Plague Institute
Россия
Россия
A. I. Bondarenko
Stavropol Research Anti-Plague Institute
Россия
Россия
A. A. Fisun
Stavropol Research Anti-Plague Institute
Россия
Россия
N. V. Abzaeva
Stavropol Research Anti-Plague Institute
Россия
Россия
G. F. Ivanova
Stavropol Research Anti-Plague Institute
Россия
Россия
S. E. Gostishcheva
Stavropol Research Anti-Plague Institute
Россия
Россия
S. M. Rudnev
Stavropol Research Anti-Plague Institute
Россия
Россия
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Review
For citations:
Budyka D.A., Bondarenko A.I., Fisun A.A., Abzaeva N.V., Ivanova G.F., Gostishcheva S.E., Rudnev S.M. Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation. Problems of Particularly Dangerous Infections. 2012;(4(114)):33-35. (In Russ.) https://doi.org/10.21055/0370-1069-2012-4-33-35
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