Construction and Investigation of the Variants of the Vaccine Strain Francisella tularensis Lacking iglC Genes. Communication 2
https://doi.org/10.21055/0370-1069-2013-4-102-105
Abstract
for BALB/c mice by an order while retaining protective properties. Strain Francisella tularensis 15 lacking two copies of the iglC gene cannot replicate in mice organism, induces weak humoral response, is fully avirulent, and has decreased protective activity. Treatment of mice with sera obtained from the animals immunized on day 49 post immunization both with the stock F. tularensis 15 strain and its variants with one or two inactivated iglC genes has provided for 100 % protection from challenge with 200 DCL of F. tularensis 15 strain. However in case of BALB/c mice exposure to virulent F. tularensis 503 and F. tularensis Schu strains (50 DCL and 25 DSL, respectively), treated with immune sera 24 hours before, registered has been only mean lifetime increase.
About the Authors
A. N. Mokrievich
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
G. M. Vakhrameeva
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
R. I. Mironova
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
T. I. Kombarova
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
I. V. Bakhteeva
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
G. M. Titareva
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
T. B. Kravchenko
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
I. A. Dyatlov
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
V. M. Pavlov
State Research Center for Applied Microbiology and Biotechnology
Russian Federation
Russian Federation
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Review
For citations:
Mokrievich A.N., Vakhrameeva G.M., Mironova R.I., Kombarova T.I., Bakhteeva I.V., Titareva G.M., Kravchenko T.B., Dyatlov I.A., Pavlov V.M. Construction and Investigation of the Variants of the Vaccine Strain Francisella tularensis Lacking iglC Genes. Communication 2. Problems of Particularly Dangerous Infections. 2013;(4):102-105. (In Russ.) https://doi.org/10.21055/0370-1069-2013-4-102-105
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