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Проблемы особо опасных инфекций

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Адгезины возбудителя чумы

https://doi.org/10.21055/0370-1069-2018-2-14-22

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Аннотация

Возбудитель чумы обладает комплексом адгезинов, обеспечивающих прикрепление возбудителя к клеткаммишеням в организме хозяина и во многом определяющих начало, характер и течение болезни. Наличие адгезинов обеспечивает транслокацию эффекторных белков в клетки-мишени млекопитающих. В обзоре представлены литературные данные как о наиболее изученных адгезинах Yersinia pestis (белках Ail и pH6 антиген), так и о недавно выявленных аутотранспортных белках различных классов, участвующих в процессах адгезии (YadBC, Yaps, Ilp). Описано их значение для патогенеза чумы, генетическая детерминированность, структура и локализация в клетке. Отмечено, что адгезины возбудителя чумы действуют на разных стадиях инфекционного процесса, выполняют множественные функции, участвуют не только в процессах прикрепления к клеткам хозяина, но также обеспечивают устойчивость к действию иммунных механизмов хозяина.

 

Об авторе

Л. М. Куклева
ФКУЗ «Российский научно-исследовательский противочумный институт «Микроб», Саратов
Россия


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Для цитирования:


Куклева Л.М. Адгезины возбудителя чумы. Проблемы особо опасных инфекций. 2018;(2):14-22. https://doi.org/10.21055/0370-1069-2018-2-14-22

For citation:


Kukleva L.M. Adhesines of the Plague Agent. Problems of Particularly Dangerous Infections. 2018;(2):14-22. (In Russ.) https://doi.org/10.21055/0370-1069-2018-2-14-22

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