Analysis of Genetic Variability of Yersinia pestis Strains (Medieval Biovar) Isolated in Natural Plague Foci of the Russian Federation and Mongolia
https://doi.org/10.21055/0370-1069-2012-4-49-53
Abstract
Carried out is the analysis of genetic peculiarities of Yersinia pestis strains (main ssp.), isolated in natural foci of the Russian Federation and Mongolia. Determined is the fact that strains of medieval biovar characterized by typical glpD1 napA2 rhaS1 genotype circulate in 7 out of 9 marmot and sandy-type foci. Strains of antique biovar characterized by glpD1 napA1 rhaS1 genotype prevail in the Trans-Baikal steppe foci. Y. pestis strains from Tuva mountain focus have similar genotype, which correlates with denitrification activity and absence of marker mutation of medieval biovar – single nucleotide substitution G→T in the 613 position of napA gene, and testifies to affiliation of these strains to antique biovar. Among Y. pestis strains isolated in Mongolia, identified are two atypical strains incapable of reducing nitrates but pertinent to antique biovar.
About the Authors
A. I. Pavlova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
G. A. Eroshenko
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
G. N. Odinokov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
L. M. Koukleva
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
N. Yu. Shavina
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
Ya. M. Krasnov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
V. V. Kutyrev
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
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Review
For citations:
Pavlova A.I., Eroshenko G.A., Odinokov G.N., Koukleva L.M., Shavina N.Yu., Krasnov Ya.M., Kutyrev V.V. Analysis of Genetic Variability of Yersinia pestis Strains (Medieval Biovar) Isolated in Natural Plague Foci of the Russian Federation and Mongolia. Problems of Particularly Dangerous Infections. 2012;(4(114)):49-53. (In Russ.) https://doi.org/10.21055/0370-1069-2012-4-49-53
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