Cultural Antigen in the Technology for Anti-Rabies Immunoglobulin Obtainment from Equine Blood Serum
https://doi.org/10.21055/0370-1069-2012-4-65-68
Abstract
week after immunization (specific activity is identified using neutralization reaction on the model of white mice and dot-blot immunoassay). This level of activity is sufficient for the fractioning of immune serum and extraction of anti-rabies immunoglobulin. Physicochemical and biological properties of the anti-rabies immunoglobulin, obtained with the help of cultural antigen technique, meet the requirements stated in the normative documentation on anti-rabies immunoglobulins extracted from equine blood serum. Specific activity level of experimental batches of anti-rabies immunoglobulin, obtained with the help of cultural technologies, corresponds to 242 and 214 IU/ml.
About the Authors
S. V. Generalov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
E. G. Abramova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
Zh. V. Matveeva
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
I. M. Zhulidov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
O. A. Lobovikova
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
R. A. Svintsov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. V. Komissarov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
M. N. Kireev
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
A. K. Nikiforov
Russian Research Anti-Plague Institute “Microbe”
Russian Federation
Russian Federation
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Review
For citations:
Generalov S.V., Abramova E.G., Matveeva Zh.V., Zhulidov I.M., Lobovikova O.A., Svintsov R.A., Komissarov A.V., Kireev M.N., Nikiforov A.K. Cultural Antigen in the Technology for Anti-Rabies Immunoglobulin Obtainment from Equine Blood Serum. Problems of Particularly Dangerous Infections. 2012;(4(114)):65-68. (In Russ.) https://doi.org/10.21055/0370-1069-2012-4-65-68
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