Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using in vitro Stimulation by Tularin
https://doi.org/10.21055/0370-1069-2012-4-73-76
Abstract
lymphocytes) isolated from mice, immunized against tularemia. Put forward is the proposition to use tularin in serological surveys and reactions
in vitro for identification of postinfectious or postvaccinal immunity to tularemia.
in vitro for identification of postinfectious or postvaccinal immunity to tularemia.
Keywords
туляремия,
поствакцинальный иммунитет,
CD69,
ИФН-γ,
ФНО-α,
tularemia,
postvaccinal immunity,
IFN-γ,
FNO-α
About the Authors
V. V. Firstova
State Research Center for Applied Microbiology and Biotechnology
Россия
Россия
V. M. Pavlov
State Research Center for Applied Microbiology and Biotechnology
Россия
Россия
T. B. Kravchenko
State Research Center for Applied Microbiology and Biotechnology
Россия
Россия
E. V. Zyrina
State Research Center for Applied Microbiology and Biotechnology
Россия
Россия
A. I. Borzilov
State Research Center for Applied Microbiology and Biotechnology
Россия
Россия
I. A. Dyatlov
State Research Center for Applied Microbiology and Biotechnology
Россия
Россия
References
1. Male D., Brostoff J., Roth D., Roitt A. Immunology. Elsevier; 2006. 552 p.
2. Cowley S.C., Elkins K.L. Immunity to Francisella. Front. Microbiol. 2011; 2:1–26. doi:10.3389/fmicb.2011.00026.
3. Cowley S.C., Hamilton E., Frelinger J.A., Su J., Forman J., Elkins K.L. CD4−CD8− T cells control intracellular bacterial infections both in vitro and in vivo. J. Exp. Med. 2005; 202(2):309–19.
4. Elkins K.L., Colombini S.M., Meierovics A.I., Chu M.C., Chou A.Y., Cowley S.C. Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma. Microbes Infect. 2010.12:28–36.
5. Elkins K.L., Cowley S.C., Bosio C.M. Innate and adaptive immunity to Francisella. Ann. N. Y. Acad. Sci. 2007; 1105:284–324.
6. Katkere B., Wilson J.E., Drake J.R. Effects of interferon-γ and Francisella tularensis elicited soluble factors on macrophage antigen processing. FASEB J. 2008; 22:1068.8.
7. Wenk M.R., Fernandis A.Z. A manual for biochemistry protocols. Vol. 3. National University of Singapore. 2007. 142 p.
8. Wickstrum J.R., Hong K.J., Bokhari S., Reed N., McWilliams N., Horvat R.T., Parmely M.J. Coactivating signals for the hepatic lymphocyte gamma interferon response to Francisella tularensis. Infect. Immun. 2007; 75:1335–42.
9. Yazg H., Uyanik M.H. et al. [Tularemia seroprevalence in the risky population living in both rural and urban areas of Erzurum]. Mikrobiyol. Bul. 2011; 45(1):67–74.
Review
For citations:
Firstova V.V., Pavlov V.M., Kravchenko T.B., Zyrina E.V., Borzilov A.I., Dyatlov I.A. Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using in vitro Stimulation by Tularin. Problems of Particularly Dangerous Infections. 2012;(4(114)):73-76. (In Russ.) https://doi.org/10.21055/0370-1069-2012-4-73-76
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